[SCF.sub.Cdc4] acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis
Article Abstract:
The role of [SCF.sub.Cdc4] as an E3 ubiquitin ligase for regulating peroxisome coactivator-1 (PGC-1) through ubiquitin-mediated proteolysis is discussed. Results suggest that the attenuation of [SCF.sub.Cdc4] dependent proteasomal degradation of PGC-1 plays an important role in the mediation of the PGC-1-dependent transcriptional response to oxidative stress.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2008
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Fine-tuning of the Escherichia coli sigma(super E) envelope stress response relies on multiple mechanisms to inhibit signal-independent proteolysis of the transmembrane anti-sigma factor, RseA
Article Abstract:
RseB, which binds to the periplasmic face of RseA, and DegS each independently, inhibits RseP cleavage of intact RseA. The function of RseB, widely conserved among bacteria using the sigma(super E) pathway, and the second role of DegS is to improve the performance characteristics of this signal transudation system.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
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